Background:
PRDX3(peroxiredoxin 3) also known as AOP-1, MER5, SP-22 or PRX3, is localized exclusively in mitochondria. The deduced 256-amino acid human AOP1 protein shares 86% amino acid sequence similarity with mouse Aop1, and significant similarity with both the human proliferation-associated gene A product and the mouse stress-induced peritoneal macrophage protein Msp23. The PRDX3 gene is mapped on 10q26.11. Expression of PRDX3 is induced by MYC and is reduced in c-myc -/- cells. Chromatin immunoprecipitation analysis spanning the entire PRDX3 genomic sequence revealed that MYC binds preferentially to a 930-bp region surrounding exon 1. Results using mitochondria-specific fluorescent probes demonstrated that PRDX3 is essential for maintaining mitochondrial mass and membrane potential in transformed rat and human cells. These data provided evidence that PRDX3 is a MYC target gene that is required to maintain normal mitochondrial function.
Synonyms:
Antioxidant Protein 1 antibody|AOP 1 antibody|AOP-1 antibody|AOP1 antibody|HBC189 antibody|MER 5 antibody|MER5 antibody|MGC104387 antibody|MGC24293 antibody|mitochondrial antibody|Mitochondrial thioredoxin dependent peroxide reductase antibody|peroxiredoxin 3 antibody|PeroxiredoxinIII antibody|Peroxiredoxin-3 antibody|Peroxiredoxin3 antibody|PRDX 3 antibody|PRDX3 antibody|PRDX3_HUMAN antibody|PRO1748 antibody|Protein MER5 homolog antibody|PRX III antibody|PRXIII antibody|Prx-III antibody|PRX3 antibody|SP 22 antibody|SP-22 antibody|SP22 antibody|Thioredoxin dependent peroxide reductase mitochondrial antibody|Thioredoxin dependent peroxide reductase precursor antibody|Thioredoxin-dependent peroxide reductase antibody
Related articles:
1. Chiribau, C. B., Cheng, L., Cucoranu, I. C., Yu, Y.-S., Clempus, R. E., Sorescu, D. FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts. J. Biol. Chem. 283: 8211-8217, 2008. 2. Nemoto, Y., Yamamoto, T., Takada, S., Matsui, Y., Obinata, M. Antisense RNA of the latent period gene (MER5) inhibits the differentiation of murine erythroleukemia cells. Gene 91: 261-265, 1990. 3. Wonsey, D. R., Zeller, K. I., Dang, C. V. The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc. Nat. Acad. Sci. 99: 6649-6654, 2002.
Storage condtions:
Keep the Peroxiredoxin 3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
Tips:
The Peroxiredoxin 3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 3(239-256aa TIKPSPAASKEYFQKVNQ), different from the related mouse and rat sequences by three amino acids.
Properties:
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Solubilization:
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
Product configuration:
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Protein Name:
Thioredoxin-dependent peroxide reductase, mitochondrial
Reacts with species::
Human. No cross reactivity with other proteins.
Purification:
Immunogen affinity purified.
Type of the antibody:
IgG polyclonal antibody
Clone:
Polyclonal antibody
Clonality:
Polyclonal antibody
Gene Full Name:
peroxiredoxin 3
Target antigen:
Peroxiredoxin 3
Analyses:
WB,IHC-P,ICC
Product form:
freeze-dried
French translation:
anticorps
Uniprot ID:
P30048
Raised in:
rabbit
Gene Name:
PRDX3