Peroxiredoxin 5 Antibody




Peroxiredoxin 5 Antibody


0,1 mg

Catalog number



320 EUR



PRDX5(peroxiredoxin 5) also known as AOEB166, ACR1,B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10, is a member of the peroxiredoxin family and may play an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes. The PRDX5 gene is mapped on 11q13.1. PRDX5 displays mitochondrial presequence features and has 3 cysteines implicated in antioxidant activity and a C-terminal SQL peroxisomal targeting sequence. Northern blot analysis revealed ubiquitous expression of a 1.0-kb PRDX5 transcript in tissues and cell lines. Functional analysis showed that PRDX5 has antioxidant activity equivalent to that of CAT. While PRDX5 was localized to fibroblasts in normal tendon, it was localized to fibroblasts and endothelial cells in degenerative tendon. PRDX5 mRNA and protein levels increased at 12 hours, and the increase in PRDX5 expression correlated with reduced peroxide levels. PRDX5 plays a protective role against oxidative stress in human cartilage.
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Related articles:
1. Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., Chumakov, P. M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. 2. Knoops, B., Clippe, A., Bogard, C., Arsalane, K., Wattiez, R., Hermans, C., Duconseille, E., Falmagne, P., Bernard, A. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. J. Biol. Chem. 274: 30451-30458, 1999. 3. Wang, M.-X., Wei, A., Yuan, J., Trickett, A., Knoops, B., Murrell, G. A. C. Expression and regulation of peroxiredoxin 5 in human osteoarthritis. FEBS Lett. 531: 359-362, 2002.
Storage condtions:
Keep the Peroxiredoxin 5 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
The Peroxiredoxin 5 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 5(166-181aa DDSLVSIFGNRRLKRF), identical to the related mouse and rat sequences.
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
Product configuration:
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Protein Name:
Peroxiredoxin-5, mitochondrial
Immunogen affinity purified.
Type of the antibody:
IgG polyclonal antibody
Polyclonal antibody
Polyclonal antibody
Gene Full Name:
peroxiredoxin 5
Target antigen:
Peroxiredoxin 5
Product form:
French translation:
Uniprot ID:
Raised in:
Gene Name:
Reacts with species::