Background:
Peroxiredoxin-4 (PRDX4) is a member of the AhpC/TSA family. PRDX4 is a cytoplasmic protein and contains one thioredoxin domain. PRDX4 exists in homodimer or heterodimer with PRDX1. PRDX4 reduces hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. In addition, PRDX4 is probably involved in redox regulation of the cell, regulating the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Properties:
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Synonym:
Peroxiredoxin-4; Antioxidant Enzyme AOE372; AOE37-2; Peroxiredoxin IV; Prx-IV; Thioredoxin Peroxidase AO372; Thioredoxin-Dependent Peroxide Reductase A0372; PRDX4
Shipping:
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Stability and Storage:
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
Formulation:
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM DTT, pH 7.2.
Endotoxin:
＜1.0 EU per µg as determined by LAL test.
Purity:
＞95% as determined by reducing SDS-PAGE.
Source:
Recombinants or rec. proteins
Sequence:
Trp38-Asn271
Group:
recombinants
Mol Mass:
33.8 kDa
Expressed Host:
E.coli
AP Mol Mass:
30 kDa
Accession:
Q13162
Fusion tag:
N-6His
Activity:
NA