Background:
PRDX5 (peroxiredoxin 5) also known as AOEB166, ACR1,B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10, is a member of the peroxiredoxin family and may play an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes. The PRDX5 gene is mapped to11q13.1. PRDX5 displays mitochondrial presequence features and has 3 cysteines implicated in antioxidant activity and a C-terminal SQL peroxisomal targeting sequence. Northern blot analysis revealed ubiquitous expression of a 1.0-kb PRDX5 transcript in tissues and cell lines. Functional analysis showed that PRDX5 has antioxidant activity equivalent to that of CAT. While PRDX5 was localized to fibroblasts in normal tendon, it was localized to fibroblasts and endothelial cells in degenerative tendon. PRDX5 mRNA and protein levels increased at 12 hours, and the increase in PRDX5 expression correlated with reduced peroxide levels. PRDX5 plays a protective role against oxidative stress in human cartilage.
Synonyms:
ACR 1 antibody|ACR1 antibody|Alu co repressor 1 antibody|Alu co-repressor 1 antibody|Alu corepressor 1 antibody|antioxidant enzyme B166 antibody|AOEB166 antibody|B166 antibody|liver tissue 2D-page spot 71B antibody|MGC117264 antibody|MGC142283 antibody|MGC142285 antibody|mitochondrial antibody|Peroxiredoxin 5 mitochondrial antibody|Peroxiredoxin 5, mitochondrial antibody|Peroxiredoxin V antibody|Peroxiredoxin-5 antibody|Peroxiredoxin5 antibody|peroxisomal antioxidant enzyme antibody|PLP antibody|PMP 20 antibody|PMP20 antibody|PRDX 5 antibody|PRDX 6 antibody|PRDX5 antibody|PRDX5_HUMAN antibody|PRDX6 antibody|Prx V antibody|Prx-V antibody|PRXV antibody|SBBI10 antibody|thioredoxin peroxidase PMP20 antibody|Thioredoxin reductase antibody|TPx type VI antibody
Related articles:
1. Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., Chumakov, P. M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304: 596-600, 2004. 2. Knoops, B., Clippe, A., Bogard, C., Arsalane, K., Wattiez, R., Hermans, C., Duconseille, E., Falmagne, P., Bernard, A. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. J. Biol. Chem. 274: 30451-30458, 1999. 3. Wang, M.-X., Wei, A., Yuan, J., Trickett, A., Knoops, B., Murrell, G. A. C. Expression and regulation of peroxiredoxin 5 in human osteoarthritis. FEBS Lett. 531: 359-362, 2002.
Storage condtions:
Keep the Peroxiredoxin 5 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
Tips:
The Peroxiredoxin 5 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
Immunogen:
E.coli-derived human Peroxiredoxin 5 recombinant protein (Position: E66-D198). Human Peroxiredoxin 5 shares 91% amino acid (aa) sequence identity with both mouse and rat Peroxiredoxin 5.
Properties:
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Solubilization:
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
Product configuration:
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Protein Name:
Peroxiredoxin-5, mitochondrial
Purification:
Immunogen affinity purified.
Type of the antibody:
IgG polyclonal antibody
Clone:
Polyclonal antibody
Clonality:
Polyclonal antibody
Target antigen:
Peroxiredoxin 5
Gene Full Name:
peroxiredoxin 5
Analyses:
WB,IHC-P,ICC
Product form:
freeze-dried
French translation:
anticorps
Uniprot ID:
P30044
Raised in:
rabbit
Gene Name:
PRDX5
Reacts with species::
human
Entrez GeneID:
25824