Background:
Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
Properties:
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Synonym:
Peroxiredoxin-1;Natural killer cell-enhancing factor A;NKEF-A;Proliferation-associated gene protein;PAG;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2;PAGA; PAGB; TDPX2
Shipping:
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
Stability and Storage:
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
Formulation:
Supplied as a 0.2 μm filtered solution of PBS, 10% glycerol, 0.1mM DTT,pH 6.0.
Endotoxin:
＜1.0 EU per µg as determined by LAL test.
Purity:
＞95% as determined by reducing SDS-PAGE.
Source:
Recombinants or rec. proteins
Group:
recombinants
Sequence:
Met1-Lys199
Mol Mass:
25.3 kDa
Fusion tag:
N,C-6His
Expressed Host:
E.coli
AP Mol Mass:
26 kDa
Accession:
Q06830
Activity:
NA