Peroxiredoxin 2 Antibody, HRP Conjugated

Basic

Information

Name

Peroxiredoxin 2 Antibody, HRP Conjugated

Size

0.1ml

Catalog number

bs-8300R-HRP

Price

350 EUR

Extended

Details

Antigen background:
Peroxiredoxin (Prx) is an antioxidant enzyme detoxifying reactive oxygen species and has a cysteine at the active site. Prx enzymes modulate various receptor signaling pathways and protect cells from oxidatively induced death. Peroxiredoxin 1 to 4 have two conserved Cys residues corresponding to Cys51 and Cys172 of mammalian Peroxiredoxin 1. The active site cysteine(Cys51) is oxidized to cysteine sulfenic acid(Cys51-SOH) when a peroxide is reduced. Because Cys51-SOH is unstable, it forms a disulfide with Cys172-SH which comes from the other subunit of the homodimer. The disulfide is then reduced back to the Prx active thiol form by the thioredoxin-thioredoxin reductase system. However, the formation of the disulfide is a slow process. Thus under oxidative stress conditions, the sulfenic intermediate(Cys51-SOH) can be easily over oxidized to cysteine sulfinic acid(Cys-SO2H) or cysteine sulfonic acid(Cys-SO3H) before it is able to form a disulfide. Recent studies suggest that over oxidized Prx can be reduced back to the active form during recovery after oxidative stress.
Synonyms:
MGC4104; Natural killer cell enhancing factor B; Natural killer cell-enhancing factor B; Natural Killer Enhancing Factor B; NKEF B; NKEF-B; NKEFB; Peroxiredoxin-2; PRDX 2; PRDX2; PRDX2_HUMAN; PRP; PRX2; PRXII; TDPX1; Thiol Specic Antioxidant 1; Thiol specic antioxidant protein; Thiol-specic antioxidant protein; Thioredoxin Dependent Peroxide Reductase 1; Thioredoxin Peroxidase 1; Thioredoxin-dependent peroxide reductase 1; Torin; TPX1; TSA.
Properties:
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
Storage conditions:
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Crossreactive species details:
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source:
KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
Specificity:
This is a highly specific antibody against Peroxiredoxin 2.
Long name:
Peroxiredoxin 2 Polyclonal Antibody, HRP Conjugated
Purification method:
This antibody was purified via Protein A.
Recommended dilutions:
WB(1:100-1000), IHC-P(1:100-500)
Host Organism:
Rabbit (Oryctolagus cuniculus)
Category:
Conjugated Primary Antibodies
Clone:
Polyclonal antibody
Crossreactivity:
Human, Mouse, Rat
Target Antigen:
Peroxiredoxin 2
Additional conjugation:
HRP Conjugated
Concentration:
1ug per 1ul
Clonality:
Polyclonal
Modification:
Unmodified
French translation:
anticorps
Tested applications:
WB, IHC-P
Modification site:
None
Gene ID number:
7001
Excitation Emission:
N/A
Conjugation:
HRP