Background:
This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22.
Description:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Antibody for research use.
Synonyms:
Antioxidant protein 1, AOP 1, AOP1, HBC189, MER5, Peroxiredoxin 3, Peroxiredoxin III, PRDX3, PRO1748, Protein MER5 homolog, Prx III, PRX3, SP 22
Properties:
If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Image1:
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab06322( Prx III Antibody) at dilution of 1:50
Image4:
HeLa cells were subjected to SDS PAGE followed by western blot with FNab06322(Prx III antibody) at dilution of 1:1000
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Recommended dilution:
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Purity:
≥95% as determined by SDS-PAGE
Purification:
Immunogen affinity purified
Specificity:
Human, Mouse, Rat
Immunogen:
peroxiredoxin 3
Tested Application:
ELISA, WB, IHC
French translation:
anticorps
Form:
liquid
Calculated MW:
25 kDa
Uniprot ID:
P30048